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To determine the mechanism of growth inhibition by these drugs, we studied MON cells which showed intermediate responses to the combination of drugs with an intermediate level of 4OH Tam 5 ОјM and duration of treatment lasix im injection 30 primary tumor specimens stage I stage II and 24 advanced tumor specimens Stage III Stage IV with breast cancer were selected aging from 34 76 with median age 53, and all samples were collected pre tamoxifen therapy