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The use of blockers of the renin- angiotensin system has been associated with improved patient and graft survival in some but not all retrospective studies, and effectively reduces proteinuria in KTRs although recent trial data suggest that this may not translate into better longer term graft outcomes 109, 154, 209. order doxycycline 5- alpha reductase inhibitors provide superior benefits to alpha blockers by preventing aur and surgery.