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Depletion of insulin content might become more pertinent if these genetic tools are used in murine models of diabetes, where insulin resistance and beta cell stress lead to insulin hypersecretion and or deficiency stromectol france A dye penetration assay using toluidine blue showed that the Lss f f K14 mice exhibited higher levels of staining than the Lss f f littermates Fig 2e, which indicated outside in skin barrier dysfunction in the Lss f f K14 mice